Tissue Culture of Isolated Human Pancreatic Islets Infected With Different Strains of Coxsackievirus B4: Assessment of Virus Replication and Effects on Islet Morphology and Insulin Release

@article{Frisk2000TissueCO,
  title={Tissue Culture of Isolated Human Pancreatic Islets Infected With Different Strains of Coxsackievirus B4: Assessment of Virus Replication and Effects on Islet Morphology and Insulin Release},
  author={Gun Frisk and Hans Diderholm},
  journal={International journal of experimental diabetes research},
  year={2000},
  volume={1},
  pages={165 - 175}
}
The aim was to study whether different strains of Coxsackievirus B4 (CBV-4) are able to infect human pancreatic islet cells in vitro and cause morphological and functional damages. Isolated islets maintained in tissue culture were infected with five well- characterised strains of CBV-4. Aliquots of the culture medium were analysed with regard to virus replication and insulin content. Infected and uninfected islets were examined by light microscopy to determine the degree of virus-induced… CONTINUE READING

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References

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Showing 1-10 of 26 references

EFFECTS OF VIRUS REPLICATION 175 cross - reactivity induced by the homologous regions in glutamic acid decarboxylase ( GAD 65 ) and 2 C protein of Coxsackievirus B 4

  • B. Conrad, R. N. Weissmahr, B. Mach
  • 1997

Antibody responses to different strains of Coxsackievirus B 4 in children with newly - diagnosed Type diabetes melli

  • G. B. Clements, D. N. Galbraith, K. W. Taylor
  • Journal of Infection
  • 1995

Childhood

  • M. Hiltunen, M. Knip, +5 authors H. K. kerblom
  • Diabetes
  • 1995

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