Tissue‐Specific Responses of Lipoprotein Lipase to Dietary Macronutrient Composition as a Predictor of Weight Gain Over 4 Years

  title={Tissue‐Specific Responses of Lipoprotein Lipase to Dietary Macronutrient Composition as a Predictor of Weight Gain Over 4 Years},
  author={Annie Ferland and Marie‐Ludivine Chateau‐Degat and Teri L. Hernandez and Robert H. Eckel},
This study evaluated if the effect of dietary macronutrient composition on adipose tissue lipoprotein lipase (ATLPL) and skeletal muscle lipoprotein lipase (SMLPL) predicted the long‐term (over 4 years) changes in body weight and composition in free‐living adults. Using a crossover design, 39 healthy subjects (n = 24 normal weight, n = 7 overweight, n = 8 obese) each followed a 2‐week isocaloric high‐carbohydrate (HC; 55% CHO:25% fat) and high‐fat (HF; 30% CHO:50% fat) diet. On day 15 of each… 
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Tissue-specific lipoprotein lipase: relationships to body composition and body fat distribution in normal weight humans.
The tissue-specific relationships oflipoprotein lipase to body composition and body fat distribution could relate to the development of obesity or the maintenance of normal body weight by the effects of the lipase on the partitioning of lipoprotein triglyceride fatty acids.
Carbohydrate balance predicts weight and fat gain in adults.
On a HC diet, the subjects who had a higher positive CHO balance on day 15 while they were inactive gained less fat mass during 4 y, a predictive effect independent of S(I), as suggested in rodents.
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Decrease of lipoprotein lipase activity in skeletal muscle in man during a short-term carbohydrate-rich dietary regime. With special reference to HDL-cholesterol, apolipoprotein and insulin concentrations.
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