Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee.

@article{Johnston2000TirilazadMI,
  title={Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee.},
  author={James H. Johnston},
  journal={Stroke},
  year={2000},
  volume={31 9},
  pages={
          2257-65
        }
}
BACKGROUND AND PURPOSE Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Studies in experimental models of ischemic stroke had suggested that tirilazad had neuroprotective properties. As a result, clinical studies were undertaken to assess the safety and efficacy of tirilazad in the treatment of acute ischemic stroke. We performed a systematic review of randomized, controlled trials that assessed the safety and efficacy of tirilazad in patients with acute… CONTINUE READING

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