Tired and apprehensive: anxiety amplifies the impact of sleep loss on aversive brain anticipation.

@article{Goldstein2013TiredAA,
  title={Tired and apprehensive: anxiety amplifies the impact of sleep loss on aversive brain anticipation.},
  author={Andrea N. Goldstein and Stephanie M. Greer and Jared M. Saletin and Allison G. Harvey and Jack B. Nitschke and Matthew P. Walker},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 26},
  pages={10607-15}
}
Anticipation is an adaptive process, aiding preparatory responses to potentially threatening events. However, excessive anticipatory responding and associated hyper-reactivity in the amygdala and insula are integral to anxiety disorders. Despite the co-occurrence of sleep disruption and anxiety disorders, the impact of sleep loss on affective anticipatory brain mechanisms, and the interaction with anxiety, remains unknown. Here, we demonstrate that sleep loss amplifies preemptive responding in… CONTINUE READING