Tirapazamine: from bench to clinical trials.

@article{Marcu2006TirapazamineFB,
  title={Tirapazamine: from bench to clinical trials.},
  author={Loredana G. Marcu and Ian Olver},
  journal={Current clinical pharmacology},
  year={2006},
  volume={1 1},
  pages={71-9}
}
Tumour hypoxia continues to remain one of the greatest challenges in the treatment of solid tumours. An important avenue to follow with both radiotherapy and chemotherapy is the development of hypoxic cytotoxins such as tirapazamine. The present review covers the history of tirapazamine from preclinical models to clinical trials. The biochemistry as well as the pharmacokinetics of this bioreductive agent are presented. Laboratory data demonstrating the enhanced effect of radiation and cisplatin… CONTINUE READING

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