Tirapazamine: a novel agent targeting hypoxic tumor cells.

  title={Tirapazamine: a novel agent targeting hypoxic tumor cells.},
  author={S Bharati Reddy and Stephen Castles Magdalena Arias Cubas Chulhyo Kim Elsa Kol Williamson},
  journal={Expert opinion on investigational drugs},
  volume={18 1},
BACKGROUND Tumor hypoxia remains one of the greatest challenges in the treatment of solid tumors, as cancer cells in these regions are resistant to killing by radiation therapy and most anticancer drugs. Tirapazamine (TPZ) is a newer class of cytotoxic drugs with selective toxicity towards hypoxic mammalian cells. OBJECTIVE This article reviews the mechanism of action, toxicity and antitumor activity of the drug and provides insights into factors that may have contributed to the disappointing… CONTINUE READING


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