Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis.

@article{Tung2012TipsST,
  title={Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis.},
  author={Jennifer J. Tung and Ian W. Tattersall and Jan Kitajewski},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2012},
  volume={2 2},
  pages={a006601}
}
Angiogenesis is the process of developing vascular sprouts from existing blood vessels. Luminal endothelial cells convert into "tip" cells that contribute to the development of a multicellular stalk, which then undergoes lumen formation. In this review, we consider a variety of cellular and molecular pathways that mediate these transitions. We focus first on Notch signaling in cell fate determination as a mechanism to define tip and stalk cells. We next discuss the current models of lumen… CONTINUE READING

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