Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease

@article{Okamura2009TippingTR,
  title={Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease},
  author={Daryl M. Okamura and Jonathan Himmelfarb},
  journal={Pediatric Nephrology},
  year={2009},
  volume={24},
  pages={2309-2319}
}
Patients with moderate to advanced chronic kidney disease or end-stage renal disease have a greatly increased cardiovascular risk that cannot be explained entirely by traditional cardiovascular risk factors. An increase in oxidative stress and inflammation have been proposed as nontraditional cardiovascular risk factors in this patient population. Oxidative stress reflects the redox balance between oxidant generation and antioxidant mechanisms. The generation of reactive oxygen species is not… CONTINUE READING
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