Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.

@article{George2009TippingTB,
  title={Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.},
  author={Cyril X. George and Zhiqun Li and Kristina M Okonski and Ann M. Toth and Ying Wang and Charles E. Samuel},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2009},
  volume={29 9},
  pages={477-87}
}
The protein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA (ADAR1) are interferon-inducible enzymes that play important roles in biologic processes including the antiviral actions of interferons, signal transduction, and apoptosis. PKR catalyzes the RNA-dependent phosphorylation of protein synthesis initiation factor eIF-2 alpha, thereby leading to altered translational patterns in interferon-treated and virus-infected cells. PKR also modulates signal transduction… CONTINUE READING
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