Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis

@inproceedings{Bentley2009TippingTB,
  title={Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis},
  author={Katie Bentley and Giovanni Mariggi and Holger Gerhardt and Paul A. Bates},
  booktitle={PLoS Computational Biology},
  year={2009}
}
Vascular abnormalities contribute to many diseases such as cancer and diabetic retinopathy. In angiogenesis new blood vessels, headed by a migrating tip cell, sprout from pre-existing vessels in response to signals, e.g., vascular endothelial growth factor (VEGF). Tip cells meet and fuse (anastomosis) to form blood-flow supporting loops. Tip cell selection is achieved by Dll4-Notch mediated lateral inhibition resulting, under normal conditions, in an interleaved arrangement of tip and non… CONTINUE READING

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The yin and yang of nature

  • O Brandman, T Meyer
  • Nature
  • 2009

Angiogenesis selectively requires the p 110 a isofrom of pi 3 k to control endothelial cell migration

  • M Graupera, J Guillermet-Guibert, LC Foukas, Phng L-K, RJ Cain
  • Nature
  • 2008

Angiogenesis selectively requires the p110 a isofrom of pi3k to control endothelial cell

  • M Graupera, J Guillermet-Guibert, LC Foukas, L-K Phng, RJ Cain
  • 2008
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