Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels.

@article{Yanamandra2011TipifarnibinducedAI,
  title={Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels.},
  author={Niranjan Yanamandra and Robert William Buzzeo and Mark C. Gabriel and Lori A. Hazlehurst and Yelenis Mari and Darrin M. Beaupre and Javier Marcos Cuevas},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={337 3},
  pages={
          636-43
        }
}
A major contributing factor to the high mortality rate associated with acute myeloid leukemia and multiple myeloma is the development of resistance to chemotherapy. We have shown that the combination of tipifarnib, a nonpeptidomimetic farnesyltransferase inhibitor (FTI), with bortezomib, a proteosome inhibitor, promotes synergistic death and overcomes de novo drug resistance in acute myeloid leukemia cell lines. Experiments were undertaken to identify the molecular mechanisms by which… CONTINUE READING

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