Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response


The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such as Myc and p53. Second, Tip60 modulates DNA-damage response (DDR) signalling, and a DDR triggered by oncogenes can counteract tumour progression. Using Eμ–myc transgenic mice… (More)
DOI: 10.1038/nature06055

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