Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity

@inproceedings{Ai2007Tip60FA,
  title={Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity},
  author={Walden Ai and Hai Bo Zheng and Xiangdong Yang and Ying Liu and Timothy C Wang},
  booktitle={Nucleic acids research},
  year={2007}
}
KLF4 is a transcription factor that is highly expressed in the gastrointestinal tract. Previously we have demonstrated that KLF4 represses HDC promoter activity in a gastric cell line through both an upstream Sp1 binding GC box and downstream gastrin responsive elements. However, the mechanism by which KLF4 inhibits HDC promoter is not well defined. In the current study, by using yeast two-hybrid screening, Tip60 was identified as a KLF4 interacting protein. Further coimmunoprecipitation and… CONTINUE READING
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