Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.

@article{Lee2001Tip60AH,
  title={Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.},
  author={Hyunjoo Lee and M Chun and Konstantin V. Kandror},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 20},
  pages={16597-600}
}
Endothelins exert their biological effects through G protein-coupled receptors. However, the precise mechanism of downstream signaling and trafficking of the receptors is largely unknown. Here we report that the histone acetyltransferase Tip60 and the histone deacetylase HDAC7 interact with one of the ET receptors, ETA, as determined by yeast two-hybrid analysis, glutathione S-transferase pull-down assays, and co-immunoprecipitation from transfected COS-7 cells. In the absence of ET-1, Tip60… CONTINUE READING