Tip60 Degradation by Adenovirus Relieves Transcriptional Repression of Viral Transcriptional Activator EIA

@inproceedings{Gupta2013Tip60DB,
  title={Tip60 Degradation by Adenovirus Relieves Transcriptional Repression of Viral Transcriptional Activator EIA},
  author={Ashish Gupta and Sudhakar Jha and Daniel A. Engel and David A. Ornelles and Anindya Dutta},
  booktitle={Oncogene},
  year={2013}
}
Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by programmed cell death. To combat these challenges, adenoviruses abrogate the cellular DNA damage response pathway. Tip60 is a lysine acetyltransferase that acetylates histones and… CONTINUE READING

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