Tip-enhanced Raman spectroscopy for the base interrogation of DNA.


A combination of scanning probe and Raman microscopies allows for the label-free chemical mapping of surfaces with spatial resolutions one to two orders of magnitude below the diffraction limit. Because Raman spectroscopy provides a highly specific molecular "fingerprint," the resulting spectra allow speciation of even highly similar chemical compounds. The… (More)
DOI: 10.1016/B978-0-12-407761-4.00026-9