Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.

@article{Aaron2007TiotropiumIC,
  title={Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.},
  author={Shawn D. Aaron and Katherine L. Vandemheen and Dean Fergusson and François Maltais and Jean Bourbeau and Roger Goldstein and Meyer S. Balter and Denis O'donnell and Andrew R McIvor and Sat Parkash Sharma and Graham Bishop and John Anthony and Robert L. Cowie and Stephen Field and Andrew L. Hirsch and Paul Hern{\'a}ndez and Robert Rivington and Jeremy Road and Victor Hoffstein and Richard V Hodder and Darcy D. Marciniuk and David McCormack and George Fox and Gerard Cox and Henry B Prins and Gordon Ford and Dominique Bleskie and Steve Doucette and Irvin Mayers and Kenneth William Chapman and Noe Zamel and Mark Fitzgerald},
  journal={Annals of internal medicine},
  year={2007},
  volume={146 8},
  pages={545-55}
}
BACKGROUND Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied. OBJECTIVE To determine whether combining tiotropium with salmeterol or fluticasone-salmeterol improves clinical outcomes in adults with moderate to severe COPD compared with tiotropium alone. DESIGN Randomized, double-blind, placebo-controlled trial conducted… CONTINUE READING
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