Tiotropium Attenuates Refractory Cough and Capsaicin Cough Reflex Sensitivity in Patients with Asthma.

@article{Fukumitsu2018TiotropiumAR,
  title={Tiotropium Attenuates Refractory Cough and Capsaicin Cough Reflex Sensitivity in Patients with Asthma.},
  author={Kensuke Fukumitsu and Yoshihiro Kanemitsu and Takamitsu Asano and Norihisa Takeda and Hiroya Ichikawa and Jennifer Maries Go Yap and Satoshi Fukuda and Takehiro Uemura and Osamu Takakuwa and Hirotsugu Ohkubo and Ken Maeno and Yutaka Ito and Tetsuya Oguri and Atsushi Nakamura and Masaya Takemura and Akio Niimi},
  journal={The journal of allergy and clinical immunology. In practice},
  year={2018},
  volume={6 5},
  pages={
          1613-1620.e2
        }
}

Figures and Tables from this paper

Increased Capsaicin Sensitivity in Severe Asthmatics Associated with Worse Clinical Outcome.

The present study suggests the association of airway neuronal dysfunction with the pathophysiology of non-type2 severe asthma with heightened C-CS is a risk factor for severe asthma.

Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma.

Methods for assessing cough sensitivity

Methodological consideration and selection are necessary for the reasonable assessment of cough sensitivity while employing cough challenges in clinical trials and some factors influencing on the accuracy of outcomes in the experimentally induced cough are detailed.

Narrative Review of the Mechanisms and Treatment of Cough in Asthma, Cough Variant Asthma, and Non-asthmatic Eosinophilic Bronchitis

The aim of this review is to discuss the mechanisms, neurophysiology, and management approaches currently available for patients presenting with chronic cough with underlying asthma, CVA, and NAEB and to shed a light on areas of further research required to elucidate the mechanisms of cough in this patient population.

Narrative Review: how long should patients with cough variant asthma or non-asthmatic eosinophilic bronchitis be treated?

  • A. Niimi
  • Medicine
    Journal of thoracic disease
  • 2021
The rationale and evidence for the need of long-term treatment for CVA and EBNA, and the development of airway remodeling due to mechanical stress to the airways exerted by long-standing coughing will be discussed.

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

A comparative perspective is outlined on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects.

The role of ATP in cough hypersensitivity syndrome: new targets for treatment

The generation, release, and regulation of ATP during airway inflammation and its role in the etiology of cough hypersensitivity syndrome are reviewed, including the potential underlying mechanism.

Intermittent Tiotropium Bromide for Episodic Wheezing: A Randomized Trial.

Intermittent tiotropium bromide treatment may be an effective alternative to current therapies for episodic wheezing and further research on safety and efficacy is indicated.

References

SHOWING 1-10 OF 70 REFERENCES

Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough

Tiotropium inhibits cough reflex sensitivity to capsaicin in subjects with acute viral URI and may occur through a mechanism other than bronchodilation.

Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects

It is suggested that cough sensitivity is potentiated by chronic airway inflammation in bronchitis but not in asthma, and cough sensitivity and bronchial responsiveness may be independently potentiation by different mechanisms resulting from chronicAirway inflammation.

Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation.

Cough sensitivity in patients with pure cough variant asthma was significantly higher than that in healthy individuals, and the cough sensitivity of patients with cough variants asthma is not necessarily identical to that of healthy individuals.

Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma

The antitussive effect of montelukast in CVA may be attributed to the attenuation of eosinophilic inflammation rather than its bronchodilatory properties.

Tiotropium Use in Pediatric Patients With Asthma or Chronic Cough

The first report to describe the use of tiotropium in pediatric patients with a physician diagnosis of asthma or chronic cough unresponsive to bronchodilators and inhaled steroids and superior to doubling the dose of ICS is described.

Tiotropium in asthma poorly controlled with standard combination therapy.

In patients with poorly controlled asthma despite the use of inhaled glucocorticoids and LABAs, the addition of tiotropium significantly increased the time to the first severe exacerbation and provided modest sustained bronchodilation.

Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma.

Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study

Airway hypersensitivity and lower baseline FEV1/FVC were associated with the appearance of wheezes, whereas a diagnosis of CVA was associated with coughing, and there are mechanistic and phenotypic differences between CVA and classic asthma during methacholine inhalation.
...