Tinman is a direct activator of midline in the Drosophila dorsal vessel.

@article{Ryu2011TinmanIA,
  title={Tinman is a direct activator of midline in the Drosophila dorsal vessel.},
  author={J R Ryu and Nima Najand and William J. Brook},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2011},
  volume={240 1},
  pages={86-95}
}
Heart development requires a conserved core of transcription factors comprised of Nkx2.5, GATA and T-box family transcription factors. In Drosophila melanogaster, the Nkx2.5 gene tinman acts upstream of many cardiac genes including the Tbx20 homolog midline, a critical regulator of heart development in both flies and vertebrates. By testing genomic fragments containing clusters of consensus Tinman-binding sites, we identified a 4.3 kb fragment 5' of midline that directs reporter expression in… CONTINUE READING
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