Tinkering Inside the Organelle

@article{Alcock2010TinkeringIT,
  title={Tinkering Inside the Organelle},
  author={Felicity Alcock and Abigail Clements and Chaille Teresa Webb and Trevor Lithgow},
  journal={Science},
  year={2010},
  volume={327},
  pages={649 - 650}
}
Debate about eukaryote evolution includes alternate views on the processes that gave rise to mitochondria. Among the questions about the evolution of eukaryotes is the debate over how they acquired the membrane-bound organelle, mitochondria. Mitochondria produce energy in nearly all eukaryotic cells (1) and regulate cell metabolism by controlling the flow of factors such as ions, amino acids, and carbohydrates between themselves and the cytoplasm. Mitochondria evolved from a bacterial… 
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38 Citations
Background Citations
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Methods Citations
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Results Citations
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38 Citations

Citation Type

Citation Type

Endosymbiont or host: who drove mitochondrial and plastid evolution?
TLDR
It is argued that evolution of mitochondrial and plastid topogenesis may better be understood as an outcome of selective pressures acting on host cell chromosomes (the "outsiders' view").
Evolution of Protein Import Pathways
Recycling and Tinkering: The Evolution of Protein Transport to and into Endosymbiotically Derived Organelles
TLDR
Today, the authors largely understand the basic prokaryotic pathways for protein transport, which were modified and extended to suffice for the much more complex membrane systems found in eukaryotes.
Back to basics: a revealing secondary reduction of the mitochondrial protein import pathway in diverse intracellular parasites.
Mosaic origin of the mitochondrial proteome
TLDR
It is observed that mitochondria neither change their subcellular compartments in the course of evolution, even when their genes do, which is consistent with the complexity hypothesis, which argues that proteins that are a part of large, multi‐subunit complexes are unlikely to undergo horizontal gene transfer.
Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin
Response to Zarsky et al.
Ancestral and derived protein import pathways in the mitochondrion of Reclinomonas americana.
TLDR
Reclinomonas americana provides direct evidence that bacterial protein transport pathways were retained, alongside the evolving mitochondrial protein import machinery, shedding new light on the process of mitochondrial evolution.
Cytochrome c oxidase: evolution of control via nuclear subunit addition.
Emerging roles of the chloroplast outer envelope membrane.
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