Tin-Protoporphyrin-Mediated Disruption In Vivo of Heme Oxygenase-2 Protein Integrity and Activity in Rat Brain

@article{Mark1992TinProtoporphyrinMediatedDI,
  title={Tin-Protoporphyrin-Mediated Disruption In Vivo of Heme Oxygenase-2 Protein Integrity and Activity in Rat Brain},
  author={Jennifer A Mark and Mahin D. Maines},
  journal={Pediatric Research},
  year={1992},
  volume={32},
  pages={324-329}
}
ABSTRACT: The ability of synthetic metalloporphyrins to suppress heme oxygenase activity and bilirubin formation has recently become of considerable clinical and experimental interest for suppression of jaundice in humans, including neonatal hyperbilirubinemia. The present investigation compares the biochemical effects of Sn- and Znprotoporphyrins on the predominant heme oxygenase iso-zyme present in the brain (HO-2) at activity, protein, and transcript levels and describes the ability of Sn… CONTINUE READING
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