Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain.

@article{Rizzi2010TimingVD,
  title={Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain.},
  author={Sabina Rizzi and Carlo Ori and Vesna Jevtovi{\'c}-Todorovi{\'c}},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1199},
  pages={
          43-51
        }
}
Rapidly accumulating evidence indicates that clinically used general anesthesia causes massive, widespread neuroapoptotic degeneration in the developing mammalian brain. Susceptibility to anesthesia-induced neurotoxicity has been documented in rats, mice, guinea pigs, primates, and in this study, piglets; in short, anesthesia-induced developmental neuroapoptosis is not species-dependent. Our findings with piglets, like those in other immature mammals, demonstrate that relatively short exposure… CONTINUE READING
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