Timing the origin of human malarias: the lemur puzzle

  title={Timing the origin of human malarias: the lemur puzzle},
  author={Maria Andre{\'i}na Pacheco and F U Battistuzzi and Randall E. Junge and Omar E Cornejo and Cathy V. Williams and Ir{\`e}ne Landau and Lydia Rabetafika and Georges Snounou and Lisa Jones-Engel and Anan{\'i}as A. Escalante},
  booktitle={BMC Evolutionary Biology},
Timing the origin of human malarias has been a focus of great interest. Previous studies on the mitochondrial genome concluded that Plasmodium in primates, including those parasitic to humans, radiated relatively recently during a process where host switches were common. Those investigations, however, assumed constant rate of evolution and tightly bound (fixed) calibration points based on host fossils or host distribution. We investigate the effect of such assumptions using different molecular… CONTINUE READING
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