Timing ovulation for intrauterine insemination with a GnRH antagonist.

@article{GmezPalomares2005TimingOF,
  title={Timing ovulation for intrauterine insemination with a GnRH antagonist.},
  author={Jos{\'e} Luis G{\'o}mez-Palomares and Beatriz Julia and B Acevedo-Mart{\'i}n and M{\'o}nica Mart{\'i}nez-Burgos and Eleuterio R. Hern{\'a}ndez and Elisabetta Ricciarelli},
  journal={Human reproduction},
  year={2005},
  volume={20 2},
  pages={
          368-72
        }
}
BACKGROUND We aimed to assess the efficacy of a GnRH antagonist in intrauterine insemination (IUI) cycles to increase number of mature ovulatory follicles and pregnancy rates. METHODS Prospective randomized study. Women (18-38 years old) with primary/secondary infertility were included. Eighty-two patients were randomly assigned to controlled ovarian stimulation (COS) consisting of rFSH + GnRH antagonist or rFSH alone. RESULTS A non-significant increase in the total amount of rFSH was seen… 
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Effectiveness of GnRH antagonist in intrauterine insemination cycles.
The addition of GnRH antagonists in intrauterine insemination cycles: a pilot study.
TLDR
The addition of GnRH antagonist in COS/IUI protocol significantly increases the number of mature follicles, however, this multifollicular recruitment is not linked to a significantly higher PR.
Multifollicular recruitment in combination with gonadotropin-releasing hormone antagonist increased pregnancy rates in intrauterine insemination cycles.
Effectiveness of gonadotropin-releasing hormone antagonists in the management of multifollicular recruitment in intrauterine insemination cycles
TLDR
Multiple doses of GnRH antagonists in COS-IUI significantly increase pregnancy rates in multifollicular cycles.
Effect of GnRH antagonists on clinical pregnancy rates in ovulation induction protocols with gonadotropins and intrauterine insemination.
TLDR
No significant improvement in the clinical pregnancy rates was observed when GnRH antagonists were used in COH + IUI cycles, despite the significant increase in the number of follicles that were > 16 mm on HCG trigger day.
Effect of GnRH antagonists in FSH mildly stimulated intrauterine insemination cycles: a multicentre randomized trial.
TLDR
In mild COH and IUI cycles, any benefit of the use of GnRH antagonists in improving pregnancy rates is <2-fold increase.
STUDY OF POSITIVE AND NEGATIVE CONSEQUENCES OF USING GNRH ANTAGONIST IN INTRAUTERINE INSEMINATION CYCLES
TLDR
At least in CC+HMG stimulated cycles for IUI, the occurrence of premature LH surge could have a useful rule and GnRH antagonist administration could be an inappropriate intervention.
The Use of Gonadotropin Releasing Hormone Antagonist in Women Undergoing Intrauterine Insemination
TLDR
The addition of a GnRH antagonist to controlled ovarian stimulation and IUI was significantly associated with an increase in pregnancy rates in multifollicular cycles and a reduction in the incidence of premature luteinization.
Clinical experience with an ovarian stimulation protocol for intrauterine insemination adopting a gonadotropin releasing hormone antagonist at low dose
TLDR
Results suggest that adding a reduced dose of GnRH antagonist to the COS for IUI cycles significantly improves the outcome of the procedure.
Effectiveness of GnRH Antagonist in the Management of Subfertile Couples Undergoing Controlled Ovarian Stimulation and Intrauterine Insemination: A Meta-Analysis
TLDR
This meta-analysis suggested that GnRH-ant can reduce the incidence of PL and increase the CPR when used in COS/IUI cycles, and it was especially useful for non-PCOS patients.
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References

SHOWING 1-10 OF 27 REFERENCES
Luteinizing hormone supplementation increases pregnancy rates in gonadotropin-releasing hormone antagonist donor cycles.
Cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination. Influence of the number of mature follicles at hCG administration.
TLDR
In COH/IUI cycles, three to four mature follicles yield improved cycle fecundity as compared to that in cycles with a smaller or larger number of follicles.
Follicular response and pregnancy among infertile women undergoing ovulation induction and intrauterine insemination.
Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome.
TLDR
The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women < 40 years of age with infertility duration < or = 6 years, who do not suffer from endometriosis.
Intrauterine insemination: a systematic review on determinants of success.
TLDR
It is concluded that although IUI is a successful contemporary treatment for appropriately selected cases of female and/or male infertility, further research is needed through well-designed studies to improve the methodologies currently utilized.
Comparison of luteal phase profile in gonadotrophin stimulated cycles with or without a gonadotrophin-releasing hormone antagonist.
TLDR
GnRH antagonists can be safely administered in gonadotrophin-stimulated IUI cycles without luteal phase supplementation because no deleterious effects of GnRH antagonist administration were noted on luteAL progesterone concentration or on the duration of the luteAl phase.
Relationship of follicle numbers and estradiol levels to multiple implantation in 3,608 intrauterine insemination cycles.
The use of GnRH antagonists in ovarian stimulation.
TLDR
Questions remain regarding pregnancy rates, the indications of their use in patients with polycystic ovary syndrome or poor responders, and in ovarian stimulation outside IVF, with regard to GnRH antagonists.
Factors influencing pregnancy rates with a combined clomiphene citrate/gonadotropin protocol for non-assisted reproductive technology fertility treatment.
Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.
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