Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity

Studies were conducted to evaluate whether the timing of administration of ICRF-187 [(+)-1,2-bis(3,5 dioxopiperazinyl-1-yl)propane] would influence the degree of cardioprotection provided by this agent against the development of doxorubicin-induced chronic cardiomyopathy. Beagle dogs (8.5–14 kg) received either doxorubicin alone (1.75 mg/kg, i. v.,n=8… CONTINUE READING