Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells.

@article{Goncalves2005TimingOT,
  title={Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells.},
  author={Maria Beatriz C V Goncalves and Julia Boyle and Daniel J Webber and Sara Jane Hall and Stephen L. Minger and Jonathan P.T. Corcoran},
  journal={Developmental biology},
  year={2005},
  volume={278 1},
  pages={60-70}
}
By culturing neural progenitor cells in the presence of retinoid receptor agonists, we have defined the components of the retinoid-signalling pathway that are important for the birth and maintenance of neuronal cells. We provide evidence that depending on the order and combination of retinoid receptors activated, different neuronal cells are obtained. Astrocytes and oligodendrocytes are predominantly formed in the presence of activated retinoic acid receptor (RAR) alpha, whereas motoneurons are… CONTINUE READING

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