Timing of retroviral infection influences anamnestic immune response in vaccinated primates.

@article{Anderson2005TimingOR,
  title={Timing of retroviral infection influences anamnestic immune response in vaccinated primates.},
  author={David E. Anderson and Anil Singapuri and Kyung Hee Kang and David C. Montefiori and Jos{\'e} Vallejo Torres},
  journal={Viral immunology},
  year={2005},
  volume={18 4},
  pages={689-94}
}
Using simian immunodeficiency virus (SIV) infection of rhesus macaques to model human immunodeficiency virus (HIV) infection of humans, we assessed whether broadly reactive vaccine-induced humoral immunity would remain broadly reactive after viral challenge, and whether there would be significant differences in anamnestic antibody responses if animals were challenged when predominately effector or memory lymphocyte populations were present. Animals immunized over a prolonged period and… CONTINUE READING