Timing of neurotransmission at fast synapses in the mammalian brain

  title={Timing of neurotransmission at fast synapses in the mammalian brain},
  author={Bernardo L. Sabatini and Wade G Regehr},
UNDERSTANDING the factors controlling synaptic delays has broad implications. On a systems level, the speed of synaptic transmission limits the communication rate between neurons and strongly influences local circuit dynamics1,2. On a molecular level, the delay from presynaptic calcium entry to postsynaptic responses constrains the molecular mechanism of vesicle fusion3. Previously it has not been possible to elucidate the determinants of synaptic delays in the mammalian central nervous system… CONTINUE READING
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