Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes.

@article{Manji2001TimingOH,
  title={Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes.},
  author={Jacqueline S. Manji and C J O'kelly and Wynne I. Leung and David M. Olson},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 4},
  pages={L799-806}
}
Hyperoxic exposure of rat pups during alveolarization (postnatal days 4-14) severely retards alveolar development. Some aspects of this inhibition are mediated by leukotrienes (LTs) and may be time sensitive. We determined 1) the effects of exposure to hyperoxia (O(2)) during discrete periods before and during alveolarization on developing alveoli and 2) whether a relationship exists between O(2) and LTs in these periods. Pups were exposed to >95% O(2) from days 1 to 4, 4 to 9, 9 to 14, or 4 to… CONTINUE READING