Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous.

@article{Weglarz2000TimingOH,
  title={Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous.},
  author={Teresa C Weglarz and Eric P. Sandgren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 23},
  pages={12595-600}
}
After surgical removal of two-thirds of the liver, remaining hepatocytes replicate and restore hepatic mass within 2 weeks. This process must be initiated by signals extrinsic to the hepatocyte, but it remains unclear whether subsequent events leading to DNA synthesis (S phase) are regulated by circulating or locally produced growth factors (a noncell autonomous response), or by a program intrinsic to the hepatocyte itself (a cell autonomous response). To identify the type of mechanism… CONTINUE READING

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