Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis.

@article{Dutt2010TimingOC,
  title={Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis.},
  author={Mahasweta Dutt and Philomela Tabuena and Elvira S. Ventura and Abdolmohamad M. Rostami and Kenneth S Shindler},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 3},
  pages={1439-45}
}
PURPOSE Acute vision loss from optic neuritis typically resolves; however, recovery is often not complete. Permanent vision loss from retinal ganglion cell (RGC) death occurs in 40% to 60% of patients. Current therapy (high-dose corticosteroids) speeds recovery but does not change final visual outcomes. Here the authors examined whether corticosteroids administered early in the disease course can prevent RGC loss in experimental optic neuritis. METHODS RGCs were retrogradely labeled with… CONTINUE READING
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