Timing of antibiotics, volume and vasoactive infusions in children with sepsis: it is all in the timing

Abstract

We share the view of van Paridon et al. [1] that robust data on fluid bolus therapy for sepsis resuscitation are needed, and looked with interest to the Alberta Sepsis Network’s recent report to add to our understanding. We note that the authors chose to exclude children who were expected to die <24 hours from presentation. We would be grateful to know how many cases were excluded on this basis. The majority of the hazard from sepsis lies in this period. We recently defined this risk in a similar cohort of children; 55 % of all sepsis deaths (78 % of these being previously healthy children) occurred within the first 24 hours [2]. Resuscitation interventions such as fluid and vasoactive drugs are guided by changes in physiology. Inasmuch as

DOI: 10.1186/s13054-015-1122-3

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Cite this paper

@inproceedings{Ray2015TimingOA, title={Timing of antibiotics, volume and vasoactive infusions in children with sepsis: it is all in the timing}, author={Samiran Ray and Mark J. Peters and Bregje M. van Paridon and Cathy Sheppard and Gonzalo Garcia Guerra and Ari Robin Joffe}, booktitle={Critical care}, year={2015} }