Timing is not Everything: Neuromodulation Opens the STDP Gate

  title={Timing is not Everything: Neuromodulation Opens the STDP Gate},
  author={Verena Pawlak and Jeffery R. Wickens and Alfredo Kirkwood and Jason N. D. Kerr},
  booktitle={Front. Syn. Neurosci.},
Spike timing dependent plasticity (STDP) is a temporally specific extension of Hebbian associative plasticity that has tied together the timing of presynaptic inputs relative to the postsynaptic single spike. However, it is difficult to translate this mechanism to in vivo conditions where there is an abundance of presynaptic activity constantly impinging upon the dendritic tree as well as ongoing postsynaptic spiking activity that backpropagates along the dendrite. Theoretical studies have… CONTINUE READING
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