Timing and mechanism of the initial cue establishing handed left–right asymmetry in Caenorhabditis elegans embryos.

@article{Schonegg2014TimingAM,
  title={Timing and mechanism of the initial cue establishing handed left–right asymmetry in Caenorhabditis elegans embryos.},
  author={Stephanie Schonegg and Anthony A. Hyman and William B. Wood},
  journal={Genesis},
  year={2014},
  volume={52 6},
  pages={572-80}
}
By the six-cell stage, embryos of Caenorhabditis elegans are morphologically L–R asymmetric with an invariant handedness that persists throughout development. We used intracellular markers to ask whether breaking of L–R symmetry could be observed at earlier stages. Observation of two- to three-cell embryos carrying intracellular markers indicated that L–R symmetry is broken concomitantly with establishment of D–V axis polarity during division of the anterior AB cell. The AB cleavage furrow… CONTINUE READING
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