Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct.

@article{Kawabori2013TimingAC,
  title={Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct.},
  author={Masahito Kawabori and Satoshi Kuroda and Masaki Ito and Hideo Shichinohe and Kiyohiro Houkin and Yuji Kuge and N. Tamaki},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2013},
  volume={33 2},
  pages={140-8}
}
Stereotactic transplantation of bone marrow stromal cells (BMSCs) enables efficient delivery to the infarct brain. This study was aimed to assess its optimal timing and cell dose for ischemic stroke. The BMSCs were harvested from the green fluorescent protein-transgenic rats and were labeled with quantum dots. The BMSCs (1 × 10(5) or 1 × 10(6) ) were stereotactically transplanted into the ipsilateral striatum of the rats subjected to permanent middle cerebral artery occlusion at 1 or 4 weeks… CONTINUE READING
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