Timing-Dependent Septal Cholinergic Induction of Dynamic Hippocampal Synaptic Plasticity

  title={Timing-Dependent Septal Cholinergic Induction of Dynamic Hippocampal Synaptic Plasticity},
  author={Zhenglin Gu and Jerrel L Yakel},
Cholinergic modulation of hippocampal synaptic plasticity has been studied extensively by applying receptor agonists or blockers; however, the effect of rapid physiological cholinergic stimuli on plasticity is largely unknown. Here, we report that septal cholinergic input, activated either by electrical stimulation or via an optogenetic approach, induced different types of hippocampal Schaffer collateral (SC) to CA1 synaptic plasticity, depending on the timing of cholinergic input relative to… CONTINUE READING
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