Timely and spatially regulated maturation of B and T cell repertoire during human fetal development

@article{Rechavi2015TimelyAS,
  title={Timely and spatially regulated maturation of B and T cell repertoire during human fetal development},
  author={Erez Rechavi and Atar Lev and Yu Nee Lee and Amos J. Simon and Yoav Yinon and Schlomo Lipitz and Ninette Amariglio and Boaz Weisz and Luigi D Notarangelo and Raz Somech},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={276ra25-276ra25}
}
Insights into the ontogeny of the human fetal adaptive immune system are of great value for understanding immunocompetence of the developing fetus. However, to date, this has remained largely uncharted territory, in large part because blood samples from healthy, early gestation fetuses have been hard to come by. In a comprehensive study, we analyzed levels of T cell receptor excision circles (TRECs), signal-joint κ receptor excision circles (sjKRECs), and intron recombination signal sequence–K… CONTINUE READING
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