Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation.

@article{Wacker2004TimedIB,
  title={Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation.},
  author={Stephan Armin Wacker and Hans J. Jansen and Claire L. McNulty and Erwin Houtzager and Antony J Durston},
  journal={Developmental biology},
  year={2004},
  volume={268 1},
  pages={207-19}
}
We report a novel developmental mechanism. Anterior-posterior positional information for the vertebrate trunk is generated by sequential interactions between a timer in the early non-organiser mesoderm and the organiser. The timer is characterised by temporally colinear activation of a series of Hox genes in the early ventral and lateral mesoderm (i.e., the non-organiser mesoderm) of the Xenopus gastrula. This early Hox gene expression is transient, unless it is stabilised by signals from the… CONTINUE READING

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