Time-window bias in case-control studies: statins and lung cancer.

@article{Suissa2011TimewindowBI,
  title={Time-window bias in case-control studies: statins and lung cancer.},
  author={Samy Suissa and Sophie Dell'aniello and Sarah Vahey and Christel Renoux},
  journal={Epidemiology},
  year={2011},
  volume={22 2},
  pages={228-31}
}
Time-related biases in cohort studies can produce illusory "beneficial" effects of medications due entirely to an artifact of the analytic design. We describe "time-window bias" in the context of a case-control study, reporting that statin use was associated with a 45% reduction in the incidence of lung cancer. This bias results from the use of time-windows of different lengths between cases and controls to define time-dependent exposures. We illustrate the bias using a population of 365,467… CONTINUE READING
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