Time-varying alterations in the f 2−f 1 DPOAE response to continuous primary stimulation I: Response characterization and contribution of the olivocochlear efferents

@article{Kujawa1995TimevaryingAI,
  title={Time-varying alterations in the f
 2−f
 1 DPOAE response to continuous primary stimulation I: Response characterization and contribution of the olivocochlear efferents},
  author={Sharon G. Kujawa and Maureen Fallon and Richard P. Bobbin},
  journal={Hearing Research},
  year={1995},
  volume={85},
  pages={142-154}
}
The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, duration, frequency) and on DPOAE type (quadratic vs cubic) and tested the hypothesis that such alterations are mediated by the olivocochlear (OC) efferents. Responses were recorded in… Expand
Time-varying alterations in the f2–f1 DPOAE response to continuous primary stimulation II. Influence of local calcium-dependent mechanisms
TLDR
Results are consistent with the hypothesis that continuous stimulation-related changes in f2-f1 DPOAE amplitude are sensitive to perilymph Ca2+ levels and to the function of L-type Ca2+, suggesting that these are not merely divalent cation effects. Expand
Microphonic and DPOAE measurements suggest a micromechanical mechanism for the ‘bounce’ phenomenon following low-frequency tones
TLDR
It is suggested that the shift in operating point is largely responsible for the increase in cochlear sensitivity, and is due to a disruption of the salt balance within the cochlea during the intense low-frequency tone. Expand
Rapid adaptation of the 2 f 1 ^ f 2 DPOAE in humans : Binaural and contralateral stimulation e ¡ ects 1
The present data were collected in humans to characterize the effects of monaural and binaural stimulation and contralateral noise on the 2f1^f2 distortion-product otoacoustic emission (DPOAE)Expand
Contralateral acoustic stimulation modulates low-frequency biasing of DPOAE: efferent influence on cochlear amplifier operating state?
TLDR
The experimental results were in good agreement with a simple model of distortion product generation and suggest that the olivocochlear efferents might change the operating state of cochlear amplification. Expand
Time course of the medial olivocochlear efferent effect on otoacoustic emissions in humans
TLDR
The suppressive effect of a contralateral broad-band noise (CBBN) on 2f1-f2 distortion product otoacoustic emissions (DPOAE) amplitude was studied in humans, showing an efferent effect outlasting CBBN stimulation. Expand
Shifting the operating point of cochlear amplification? Impact of low frequency biasing and contralateral sound stimulation on DPOAE
The mammalian efferent medial olivo-cochlear system is known to modulate active amplification of low-level sound in the cochlea. We investigated the effect of contralateral acoustic stimulationExpand
Modifications of a single saturating non-linearity account for post-onset changes in 2f1-f2 distortion product otoacoustic emission.
TLDR
By establishing that the 2f1-f2 onset changes reflect a shift in the growth-function notch, it is possible to predict the temporal behavior of DPOAEs in the two-dimensional space of the amplitude of the primaries and for their different frequency ratios. Expand
Human efferent adaptation of DPOAEs in the L 1,L 2 space
TLDR
The 2f(1)-f2 results suggest that a potentially important area for adaptation measures exists in the L1,L2 space, when L1 is lower than L2, which combination of primary-tone levels can lead to large DPOAE adaptation effects that may be related to a notch in the D POAE response/growth or input/output (I/O) function. Expand
Chronic low-level noise exposure alters distortion product otoacoustic emissions
TLDR
Results demonstrate that this noise induces frequency-dependent and very localized reductions in 2f1-f2 DPOAE input/output (I/O) functions, which lend support to the conclusions of Chen et al. (1995) that chronic low-level noise exposure induces molecular changes in the OHCs which may, in turn, alter cochlear function. Expand
Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f2. I. Basic findings in rabbits
TLDR
These findings, along with the effects of tonal exposures designed to fatigue regions above f(2), and instances in which DPOAE level was dependent upon the amount of suppression/enhancement, suggested that the interactions of two D POAE-generator sources contributed, in some manner, to these phenomena. Expand
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Qualitatively similar variations in f2-f1 DPOAE amplitude, in the absence of 2f1-f2 amplitude variations, were found in all ears tested, supporting the hypothesis of a dissociation of the generators of the two D POAEs. Expand
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