Time to Talk SENS: Critiquing the Immutability of Human Aging

@article{Grey2002TimeTT,
  title={Time to Talk SENS: Critiquing the Immutability of Human Aging},
  author={A. D. Grey and B. Ames and J. Andersen and A. Bartke and J. Campisi and C. Heward and R. W. McCarter and G. Stock},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={959}
}
Aging is a three‐stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect. These toxins cause damage, of which a small proportion cannot be removed by any endogenous repair process and thus accumulates. This accumulating damage ultimately drives age‐related degeneration. Interventions can be designed at all three stages. However, intervention in metabolism can only modestly postpone pathology, because production of… Expand
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