Time series modeling of heroin and morphine drug action

  title={Time series modeling of heroin and morphine drug action},
  author={W. Tschacher and R. Haemmig and N. Jacobshagen},
  • W. Tschacher, R. Haemmig, N. Jacobshagen
  • Published 2002
  • Medicine
  • Psychopharmacology
  • Abstract Rationale. Clinical observations and recent findings suggested different acceptance of morphine and heroin by intravenous drug users in opiate maintenance programs. We postulated that this is caused by differences in the perceived effects of these drugs, especially how desired and adverse effects of both drugs interacted. Objectives. We measured the desired and adverse effects of high doses of injected morphine and heroin in patients to determine the causal interactions between both… CONTINUE READING
    22 Citations

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Cerebral blood flow effects of acute intravenous heroin administration
    • 14
    High levels of morphine-6-glucuronide in street heroin addicts
    • 31
    Repeated Exposures to Heroin and/or Cadmium Alter the Rate of Formation of Morphine Glucuronides in the Rat
    • 23
    • PDF
    Neurobehavioral Toxicology of Substances of Abuse
    • 5
    Pattern of regional cerebral blood-flow changes induced by acute heroin administration--a perfusion MRI study.
    • 15
    • PDF
    Modulatory Effect of Environmental Context and Drug History on Heroin-Induced Psychomotor Activity and Fos Protein Expression in the Rat Brain
    • 40
    • PDF
    Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
    • 25
    • PDF


    Effects of High-Dose Heroin versus Morphine in Intravenous Drug Users: A Randomised Double-Blind Crossover Study
    • 23
    Drug-induced mood changes in man. I. Observations on healthy subjects, chronically ill patients, and postaddicts.
    • 235
    Affective changes in chronic opiate use.
    • 12
    Psychopathology and Mood During Heroin Use
    • 31
    Analysis of crisis intervention processes.
    • 9
    A (eds) (2002) rztliche Verschreibung von Bet ubungsmitteln. Praktische Umsetzung und wichtigste Ergebnisse
    • 2002
    Koda-1 in Bern: medical aspects. In: Bammer G (ed) Stage 2 working papers: feasibility research into the controlled availability of opioids
    • National Centre for Epidemiology and Population Health,
    • 1997