Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

@inproceedings{Penas2019TimeSM,
  title={Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis},
  author={Clara Penas and Marie E. Maloof and Vasileios Stathias and Jun Long and Sze Kiat Tan and Jos{\'e} Manuel Su{\'a}rez Mier and Yin Fang and Camilo Valdes and Jezabel Rodriguez-Blanco and Cheng-Ming Chiang and David J. Robbins and Daniel J. Liebl and Jae K. Lee and Mary E. Hatten and Jennifer Clarke and Nagi G. Ayad},
  booktitle={Nature Communications},
  year={2019}
}
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. To better define the pathways controlling the most abundant neuronal cells in the mammalian cerebellum, cerebellar granule cell progenitors (GCPs), we performed RNA-sequencing of GCPs exiting the cell cycle. Time… CONTINUE READING

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Brd4 Is Required for Granule Cell Progenitor Proliferation

Marie E. Maloof
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