Time series for modelling counts from a relapsing-remitting disease: application to modelling disease activity in multiple sclerosis.

@article{Albert1994TimeSF,
  title={Time series for modelling counts from a relapsing-remitting disease: application to modelling disease activity in multiple sclerosis.},
  author={Paul S. Albert and Henry F. McFarland and Marshall E. Smith and Joseph A. Frank},
  journal={Statistics in medicine},
  year={1994},
  volume={13 5-7},
  pages={453-66}
}
Many chronic diseases are relapsing-remitting diseases, in which subjects alternate between periods with increasing and decreasing disease activity; relapsing-remitting multiple sclerosis is an example. This paper proposes two classes of models for sequences of counts observed from a relapsing-remitting disease. In the first, the relapsing-remitting nature of the data is modelled by a Poisson time series with a periodic trend in the mean. In this approach, the mean is expressed as a function of… CONTINUE READING