Time response of cytochrome P450 1A2 activity on cessation of heavy smoking.

  title={Time response of cytochrome P450 1A2 activity on cessation of heavy smoking.},
  author={Mirko S Faber and Uwe Fuhr},
  journal={Clinical pharmacology and therapeutics},
  volume={76 2},
BACKGROUND AND OBJECTIVE Cytochrome P450 (CYP) 1A2 activity is induced by cigarette smoking. Thus smoking cessation in patients while they are undergoing therapy with a CYP1A2 substrate such as theophylline or clozapine increases its concentrations and may cause adverse effects. Our objective was to determine the time course of CYP1A2 activity changes after smoking cessation in heavy smokers as the basis for dosing adaptation schemes. METHODS The study was conducted in 8 men and 4 women (all… CONTINUE READING


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