Time-resolved quantitative analysis of CCK1 receptor-induced intracellular calcium increase.

@article{Staljanssens2012TimeresolvedQA,
  title={Time-resolved quantitative analysis of CCK1 receptor-induced intracellular calcium increase.},
  author={Dorien Staljanssens and Winnok H De Vos and Peter Willems and John Van Camp and Guy Smagghe},
  journal={Peptides},
  year={2012},
  volume={34 1},
  pages={219-25}
}
Cholecystokinin (CCK) is a gastrointestinal hormone, which regulates many physiological functions such as satiety by binding to the CCK receptor (CCKR). Molecules, which recognize this receptor can mimic or block CCK signaling and thereby influence CCKR-mediated processes. We have set up a quantitative heterologous assay with CHO cells over-expressing the rat CCK1 receptor to screen for such candidate molecules. Receptor activation, induced by agonist binding, is followed by an intracellular… CONTINUE READING

Similar Papers

Loading similar papers…