Time-resolved imaging of Ca(2+)-dependent aequorin luminescence of microdomains and QEDs in synaptic preterminals.

@article{Silver1994TimeresolvedIO,
  title={Time-resolved imaging of Ca(2+)-dependent aequorin luminescence of microdomains and QEDs in synaptic preterminals.},
  author={Randi B. Silver and Mutsuyuki Sugimori and Eric J. Lang and Rodolfo Llin{\'a}s},
  journal={The Biological bulletin},
  year={1994},
  volume={187 3},
  pages={293-9}
}
Localized elevation of intracellular free calcium [Ca2+]i concentration serves as the trigger for a wide variety of physiological processes, e.g., neurotransmitter release at most chemical synapses (1-3). The details of the mechanisms that regulate these processes are still unresolved (3-6), but they must involve precise temporal sequences of molecular events initiated by a transient localized elevation of Ca2+ concentration (i.e., a Ca2+ microdomain [3,7-15]). A microdomain is defined as an… CONTINUE READING