Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

@article{Schlage2014TimeresolvedAO,
  title={Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.},
  author={Pascal Schlage and Fabian E Egli and Paolo Nanni and Lauren W Wang and Jayachandran N Kizhakkedathu and Suneel S. Apte and Ulrich Auf dem Keller},
  journal={Molecular & cellular proteomics : MCP},
  year={2014},
  volume={13 2},
  pages={
          580-93
        }
}
Proteolysis is an irreversible post-translational modification that affects intra- and intercellular communication by modulating the activity of bioactive mediators. Key to understanding protease function is the system-wide identification of cleavage events and their dynamics in physiological contexts. Despite recent advances in mass spectrometry-based proteomics for high-throughput substrate screening, current approaches suffer from high false positive rates and only capture single states of… CONTINUE READING

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