Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution

@inproceedings{Buck2007TimeresolvedNM,
  title={Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution},
  author={Janina Buck and Boris F{\"u}rtig and Jonas Noeske and Jens W{\"o}hnert and Harald Schwalbe},
  year={2007}
}
Structural transitions of RNA between alternate conformations with similar stabilities are associated with important aspects of cellular function. Few techniques presently exist that are capable of monitoring such transitions and thereby provide insight into RNA dynamics and function at atomic resolution. Riboswitches are found in the 5′-UTR of mRNA and control gene expression through structural transitions after ligand recognition. A time-resolved NMR strategy was established in conjunction… CONTINUE READING

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