Time out: developmental regulation of heterochromatic silencing in Drosophila

  title={Time out: developmental regulation of heterochromatic silencing in Drosophila},
  author={B. Y. Lu and Joel C. Eissenberg},
  journal={Cellular and Molecular Life Sciences CMLS},
Transcriptional silencing by heterochromatin represents a model for developmental gene silencing. Current models of heterochromatin envision DNA-protein complexes that prevent access by euchromatic transcription factors. Here, we summarize the evidence that heterochromatin acts at the chromatin level to silence genes and the status of current models of heterochromatin silencing, and we highlight some recent progress in understanding the composition and regulation of heterochromatin in… CONTINUE READING

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Develop - mental timing and tissue specificity of heterochromatic position - effect silencing

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